One‐Pot Three‐Component Synthesis of Alkylthio‐/Arylthio‐ Substituted Imidazo[1, 2‐a]pyridine Derivatives via C(sp2)–H Functionalization. Issue 13 (23rd June 2017)

• Record Type: Journal Article
• Authors: Zhu, Wenhui; Ding, Yingcai; Bian, Zhaogang; Xie, Ping; Xu, Baojun; Tang, Qiujie; Wu, Wei; Zhou, Aihua
• Is Part Of: Advanced synthesis & catalysis. Volume 359:Issue 13(2017)
• Page Start: 2215
• Page End: 2221
• Publication Date: 2017-06-23
• Subjects: C(sp2)–H functionalization -- C−S bond formation -- imidazo[1, 2-a]pyridines -- sulfenylation; Catalysis -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Chemistry -- Periodicals; Chemistry, Technical -- Periodicals; Chemistry -- Periodicals; Catalysis -- Periodicals; Technology, Pharmaceutical -- Periodicals; 547.2
• DOI: 10.1002/adsc.201601431
• Languages: English
• ISSNs: 1615-4150

Abstract

Abstract: Sulfenylation is an important transformation to generate C−S bonds in organic synthesis. Here, two three‐component synthetic protocols have been developed by using imidazo[1, 2‐ a ]pyridine, inorganic, odorless S8 and alcohols or arylboronic acids as reactants to make alkylthio‐/arylthio‐substituted imidazo[1, 2‐ a ]pyridine derivatives via C( sp 2 )–H functionalization. The reactions proceeded with high efficiency and broad functional group tolerance, affording the products regioselectively and in good yields. Abstract :