Benzylphenylpyrrolizinones with Anti‐amyloid and Radical Scavenging Effects, Potentially Useful in Alzheimer's Disease Treatment. (12th April 2017)

• Record Type: Journal Article
• Authors: Jourdan, Jean‐Pierre; Since, Marc; El Kihel, Laïla; Lecoutey, Cédric; Corvaisier, Sophie; Legay, Rémi; Sopková‐de Oliveira Santos, Jana; Cresteil, Thierry; Malzert‐Fréon, Aurélie; Rochais, Christophe; Dallemagne, Patrick
• Is Part Of: ChemMedChem. Volume 12:Number 12(2017)
• Page Start: 913
• Page End: 916
• Publication Date: 2017-04-12
• Subjects: Alzheimer′s disease -- β-amyloid -- antioxidants -- MTDL -- pyrrolizinones; Pharmaceutical chemistry -- Periodicals; 615.19005
• DOI: 10.1002/cmdc.201700102
• Languages: English
• ISSNs: 1860-7179

Abstract

Abstract: Herein we describe the drug design steps developed to increase the radical scavenging and β‐amyloid aggregation inhibitory activities of a previously described series of benzylidenephenylpyrrolizinones. Among the newly synthesized derivatives, some benzylphenylpyrrolizinones exhibited interesting results in regard to those activities. Initial druggability parameters were measured, and suggest these compounds as a suitable starting point for potential alternatives in treating Alzheimer's disease. Abstract : Pick up & break up : This study aimed at increasing the radical scavenging and anti‐Aβ‐aggregation activities of a series of benzylidenephenylpyrrolizinones. Some of the new derivatives showed promising results in this regard. These compounds could serve as a good starting point for new drugs to treat Alzheimer's disease.