Investigation of the effect of medium in the preparation of alendronate: till now the best synthesis in the presence of an ionic liquid additive. Issue 3 (3rd May 2017)

• Record Type: Journal Article
• Authors: Nagy, Dávid Illés; Grün, Alajos; Garadnay, Sándor; Greiner, István; Keglevich, György
• Is Part Of: Heteroatom chemistry. Volume 28:Issue 3(2017)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2017-05-03
• Subjects: alendronate -- synthesis -- γ‐aminobutyric acid -- P(III)‐reagents -- sulfolane -- ionic liquids; Heterocyclic chemistry -- Periodicals; 547.59
• DOI: 10.1002/hc.21370
• Languages: English
• ISSNs: 1042-7163

Abstract

Abstract: The synthesis of the drug alendronate from γ‐aminobutyric acid and phosphorus trichloride/phosphorous acid as the P‐reagents is revisited using methanesulfonic acid and sulfolane as solvents and ionic liquids (ILs) as additives according to a novel approach. Besides elaborating efficient synthetic methods with a record yield of up to 80%, the misleading literature data were also clarified. It is a novel trend to use ILs as only catalysts or additives and not as solvents.