A man‐made disease: Fetal neonatal alloimmune thrombocytopenia due to incompatibility between oocyte donor and gestational mother. Issue 8 (18th January 2017)

• Record Type: Journal Article
• Authors: Barg, Assaf Arie; Ifrah, Aviya Dvir; Strauss, Tzipi; Simchen, Michal J.; Orvieto, Raoul; Rosenberg, Nurit; Kenet, Gili
• Is Part Of: Pediatric blood & cancer. Volume 64:Issue 8(2017)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2017-01-18
• Subjects: HPA -- neonatal thrombocytopenia -- oocyte donor -- surrogate pregnancy -- Turner syndrome; Tumors in children -- Periodicals; Blood -- Diseases -- Periodicals; Cancer in children -- Periodicals; 618.92
• DOI: 10.1002/pbc.26447
• Languages: English
• ISSNs: 1545-5009

Abstract

Abstract: The incompatibility causing fetal and neonatal alloimmune thrombocytopenia (FNAIT) results from a fetus inheriting a paternal human platelet antigen (HPA), which is different from the maternal HPA. We present a unique case of FNAIT in a pregnancy involving an oocyte recipient mother with Turner syndrome. This is the first report of FNAIT in which the suggested mechanism involves antibodies produced by a gestational mother against the incompatible HPA of the oocyte donor.