A pH‐Responsive DNAsome from the Self‐Assembly of DNA–Phenyleneethynylene Hybrid Amphiphile. Issue 35 (5th June 2017)

• Record Type: Journal Article
• Authors: Albert, Shine K.; Golla, Murali; Thelu, Hari Veera Prasad; Krishnan, Nithiyanandan; Varghese, Reji
• Is Part Of: Chemistry. Volume 23:Issue 35(2017)
• Page Start: 8348
• Page End: 8352
• Publication Date: 2017-06-05
• Subjects: amphiphiles -- DNA nanostructures -- responsive systems -- self-assembly -- vesicles; Chemistry -- Periodicals; 540
• DOI: 10.1002/chem.201701446
• Languages: English
• ISSNs: 0947-6539

Abstract

Abstract: A pH‐responsive DNAsome derived from the amphiphilicity‐driven self‐assembly of DNA amphiphile containing C‐rich DNA sequence is reported. The acidification of DNAsome induces a structural change of C‐rich DNA from random coil to an i‐motif structure that triggers the disassembly of DNAsome and its subsequent morphological transformation into an open entangled network. The encapsulation of a hydrophobic guest into the membrane of DNAsome and its pH‐triggered release upon acidification of DNAsome is also demonstrated. Abstract : Amphiphilicity‐driven self‐assembly of DNA amphiphile containing C‐rich DNA as the hydrophilic segment leads to the formation of DNAsome at basic pH (7.3). The acidification of DNAsome induces a structural change of C‐rich DNA from random coil to an i‐motif structure that triggers the disassembly of DNAsome and its subsequent morphological transformation into an open entangled network in a reversible manner.