Luminescence materials for pH and oxygen sensing in microbial cells – structures, optical properties, and biological applications. (18th August 2017)

• Record Type: Journal Article
• Authors: Zou, Xianshao; Pan, Tingting; Chen, Lei; Tian, Yanqing; Zhang, Weiwen
• Is Part Of: Critical reviews in biotechnology. Volume 37:Number 6(2017)
• Page Start: 723
• Page End: 738
• Publication Date: 2017-08-18
• Subjects: pH sensors -- oxygen sensors -- dual sensors -- intracellular sensors -- extracellular sensors -- multifunctional sensors; Biotechnology -- Periodicals; Biotechnology -- Periodicals; Review Literature -- Periodicals; Public Health -- Periodicals; Environment -- Periodicals; Industry -- Periodicals; Biotechnology; Review Literature; Public Health; Environment; Industry; 660.6
• DOI: 10.1080/07388551.2016.1223011
• Languages: English
• ISSNs: 0738-8551

Abstract

Abstract: Luminescence including fluorescence and phosphorescence sensors have been demonstrated to be important for studying cell metabolism, and diagnosing diseases and cancer. Various design principles have been employed for the development of sensors in different formats, such as organic molecules, polymers, polymeric hydrogels, and nanoparticles. The integration of the sensing with fluorescence imaging provides valuable tools for biomedical research and applications at not only bulk-cell level but also at single-cell level. In this article, we critically reviewed recent progresses on pH, oxygen, and dual pH and oxygen sensors specifically for their application in microbial cells. In addition, we focused not only on sensor materials with different chemical structures, but also on design and applications of sensors for better understanding cellular metabolism of microbial cells. Finally, we also provided an outlook for future materials design and key challenges in reaching broad applications in microbial cells.