Placental expression of sFlt-1 and PlGF in early preeclampsia vs. early IUGR vs. age-matched healthy pregnancies. (3rd April 2017)

• Record Type: Journal Article
• Authors: Hoeller, Alice; Ehrlich, Laura; Golic, Michaela; Herse, Florian; Perschel, Frank H.; Siwetz, Monika; Henrich, Wolfgang; Dechend, Ralf; Huppertz, Berthold; Verlohren, Stefan
• Is Part Of: Hypertension in pregnancy. Volume 36:Number 2(2017)
• Page Start: 151
• Page End: 160
• Publication Date: 2017-04-03
• Subjects: sFlt-1/PlGF -- sFlt-1; PlGF -- preeclampsia -- intrauterine growth restriction; Hypertension in pregnancy -- Periodicals; Pregnancy -- Complications -- Periodicals; 618.3261
• DOI: 10.1080/10641955.2016.1273363
• Languages: English
• ISSNs: 1064-1955

Abstract

ABSTRACT: Objective : To investigate whether differences between early preeclampsia and early fetal growth restriction can be explained by differential placental expression patterns of sFlt-1, Flt-1, and PlGF. Methods : Placental tissues and maternal blood samples from six cases of preeclampsia, seven IUGR, and six age-matched controls were studied for mRNA and protein levels as well as protein localization and expression intensity. Results : Neither placental PlGF mRNA and protein expression nor placental villous trophoblast expression intensity of PlGF was altered by placental dysfunction. Conclusion : High sFlt-1 concentrations may account for diminished maternal serum PlGF levels.