A Scalable and Versatile Synthesis of Oxime‐Based Hormone Dimers and Gels for Sustained Release. Issue 13 (18th April 2017)

• Record Type: Journal Article
• Authors: Bennett, Christopher W.; Collins, Joe; Xiao, Zeyun; Klinger, Daniel; Connal, Luke A.
• Is Part Of: Chemistry, an Asian journal. Volume 12:Issue 13(2017)
• Page Start: 1456
• Page End: 1460
• Publication Date: 2017-04-18
• Subjects: click chemistry -- dimers -- hormones -- organogels -- oximes; Chemistry -- Periodicals; 540.5
• DOI: 10.1002/asia.201700288
• Languages: English
• ISSNs: 1861-4728

Abstract

Abstract: Well‐defined steroid hormone dimers and organogels were produced via a facile and scalable synthesis using oxime click chemistry. The versatile synthetic procedure extends to a wide range of hormones and linker groups exemplified here through the synthesis of cortisol‐ and progesterone‐dimers linked via hydrophobic, hydrophilic or functional groups. This method was also extended to the synthesis of cortisone‐based organogels. Owing to the dynamic nature of the oxime bond, the hormone‐based materials are degradable via acidic hydrolysis and transoximination representing new materials for the controlled release of steroid hormones. Abstract : Keeping hormones in balance : Well‐defined steroid hormone dimers and organogels were produced via a facile and scalable synthesis using oxime click chemistry. Owing to the dynamic oxime bonds, the hormone‐based materials are degradable via acidic hydrolysis and transoximination, therefore representing new materials for the controlled release of steroid hormones.