Anaphylactic reaction to tranexamic acid in an adolescent undergoing posterior spinal fusion. Issue 7 (21st March 2017)

• Record Type: Journal Article
• Authors: Chiem, Jennifer; Ivanova, Iskra; Parker, Andrew; Krengel, Walter; Jimenez, Nathalia
• Editors: Polaner, David
• Is Part Of: Paediatric anaesthesia. Volume 27:Issue 7(2017:Jul.)
• Page Start: 774
• Page End: 775
• Publication Date: 2017-03-21
• Subjects: anaphylaxis -- antifibrinolytic agents -- tranexamic acid -- scoliosis -- spinal fusion -- pediatrics; Pediatric anesthesia -- Periodicals; 617.96798
• DOI: 10.1111/pan.13141
• Languages: English
• ISSNs: 1155-5645

Abstract

Summary: Tranexamic acid is an anti‐fibrinolytic agent frequently used in pediatric surgery. Common side effects include nausea, flushing, and headache, but in rare instances, it may produce anaphylaxis; with only one previously reported case in a 72‐year‐old man. We report a case of a delayed anaphylactic reaction in a pediatric patient undergoing posterior spine fusion; and discuss the intraoperative management of the acute event, immunologic confirmation, and subsequent anesthetic approach.