Type 2 diabetes is associated with low muscle mass in older adults. (February 2014)

• Record Type: Journal Article
• Authors: Kim, Kyung‐Soo; Park, Kyung‐Sun; Kim, Moon‐Jong; Kim, Soo‐Kyung; Cho, Yong‐Wook; Park, Seok Won
• Other Names: Akishita Masahiro guestEditor.; Arai Hidenori guestEditor.; Chen Liang‐Kung guestEditor.
• Is Part Of: Geriatrics and gerontology international. Volume 14(2014)Supplement 1
• Page Start: 115
• Page End: 121
• Publication Date: 2014-02
• Subjects: elderly diabetes -- sarcopenia -- type 2 diabetes; Geriatrics -- Periodicals; Gerontology -- Periodicals; Geriatrics -- Japan -- Periodicals; Gerontology -- Japan -- Periodicals; 618.97
• DOI: 10.1111/ggi.12189
• Languages: English
• ISSNs: 1444-1586

Abstract

Abstract : Aims: Our aim was to clarify the association between type 2 diabetes and the risk of low muscle mass in older adults. Methods: In the present study, 414 adults aged 65 years or older (144 patients with type 2 diabetes and 270 control participants) were included. Body composition was measured by dual‐energy X‐ray absorptiometry. Low muscle mass was defined as the appendicular skeletal muscle mass/height 2 (ASM/Ht 2 ) or appendicular skeletal muscle mass/weight (ASM/Wt) of <2 SD below the sex‐specific normal mean of the young reference group, or <lower 20th percentile of total body skeletal muscle mass/weight (TSM/Wt) from control participants. Results: Older men with type 2 diabetes showed significantly lower appendicular skeletal muscle mass than those without diabetes (19.5 ± 3.5 kg vs 21.0 ± 2.8 kg, P < 0.001). The prevalence of low muscle mass was consistently higher in older men with diabetes than those without diabetes defined by ASM/Ht 2 (57.6% vs 41.5%, P = 0.040), ASM/Wt (23.7% vs 12.3%, P = 0.046) and TSM/Wt (49.2% vs 20.0%, P < 0.001). In older women with diabetes, the prevalence of low muscle mass was higher than those without diabetes by ASM/Wt (25.9% vs 15.0%, P = 0.044) and TSM/Wt (32.9% vs 20.0%, P = 0.030), but not by ASM/Ht 2 (7.1% vs 8.6%, P = 0.685). The risk of low muscle mass was approximately two‐ to fourfold higher in older adults with type 2 diabetes, even after adjusting for age, body mass index, current smoking and other risk factors. Conclusions: In Korean older adults, type 2 diabetes is associated with low muscle mass.Geriatr Gerontol Int 2014; 14 (Suppl. 1): 115–121.