Driving the Morita–Baylis–Hillman Reaction to a Multicomponent Organic Transformation. Issue 4 (26th November 2013)

• Record Type: Journal Article
• Authors: Guillouzic, Anne‐Françoise; Montel, Sonia; Laborde, Coralie; Volle, Jean‐Noël; Pirat, Jean‐Luc; Virieux, David
• Is Part Of: European journal of organic chemistry. Issue 4(2014)
• Page Start: 788
• Page End: 796
• Publication Date: 2013-11-26
• Subjects: Multicomponent reactions -- Domino reactions -- Phosphorus -- Alkenes -- Aldehydes; Chemistry, Organic -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1002/ejoc.201301226
• Languages: English
• ISSNs: 1434-193X

Abstract

Abstract: The combination of a trivalent phosphorus reagent with an aldehyde and a Michael olefin in the presence of water led to the formation of functionalized phosphine oxides. This approach turned the Lewis base organocatalyzed Morita–Baylis–Hillman reaction into a multicomponent organic transformation to provide rapid access to polyfunctionalized molecules. Abstract : The combination of a trivalent phosphorus reagent with an aryl aldehyde and a Michael olefin in the presence of water led to the formation of functionalized phosphine oxides. This approach turned the Lewis base organocatalyzed Morita–Baylis–Hillman reaction into a multicomponent reaction to provide rapid access to polyfunctionalized molecules.