Higher plasma leptin is associated with higher risk of androgenetic alopecia in men. Issue 6 (June 2017)

• Record Type: Journal Article
• Authors: Yang, Chao‐Chun; Chung, Pei‐Lun; Lin, Li‐Yu; Hughes, Michael W.; Tsai, Yau‐Sheng
• Other Names: Botchkareva Natalia guestEditor.; Messenger Andrew guestEditor.
• Is Part Of: Experimental dermatology. Volume 26:Issue 6(2017)
• Page Start: 524
• Page End: 526
• Publication Date: 2017-06
• Subjects: adipocytes -- androgenetic alopecia -- body mass index -- leptin -- transforming growth factor‐β1; Dermatology -- Periodicals; 616.5
• DOI: 10.1111/exd.13369
• Languages: English
• ISSNs: 0906-6705

Abstract

Abstract: In addition to genetics and androgens, novel factors could play a role in androgenetic alopecia (AGA). This study aims to investigate the association between plasma leptin level with the risk and severity of AGA in men. Forty‐eight subjects were enrolled including 29 AGA and 19 non‐AGA subjects. The plasma leptin level was significantly higher in AGA subjects, compared to non‐AGA subjects (4.45 vs 2.76 ng/mL, P <.05). A higher plasma leptin levels were positively correlated with the risk of developing AGA in multivariate logistic analysis (odds ratio=2.77, P <.05). Leptin from the circulation might impact the development of AGA.