Risk factors of human herpesvirus 6 encephalitis/myelitis after allogeneic hematopoietic stem cell transplantation. Issue 3 (12th April 2017)

• Record Type: Journal Article
• Authors: Miyashita, Naohiro; Endo, Tomoyuki; Onozawa, Masahiro; Hashimoto, Daigo; Kondo, Takeshi; Fujimoto, Katsuya; Kahata, Kaoru; Sugita, Junichi; Goto, Hideki; Matsukawa, Toshihiro; Hashino, Satoshi; Teshima, Takanori
• Is Part Of: Transplant infectious disease. Volume 19:Issue 3(2017)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2017-04-12
• Subjects: hematopoietic stem cell transplantation -- human herpesvirus 6 -- mycophenolate mofetil; Transplantation of organs, tissues, etc -- Complications -- Periodicals; Communicable diseases -- Periodicals; Infection -- Periodicals; 617.01
• DOI: 10.1111/tid.12682
• Languages: English
• ISSNs: 1398-2273

Abstract

Abstract: Background: Human herpesvirus 6 (HHV‐6) encephalitis/myelitis is now a well‐known complication after allogeneic stem cell transplantation (allo‐HSCT), particularly after cord blood transplantation (CBT). In this study, we evaluated the risk factors of HHV‐6 encephalitis/myelitis. Methods: We evaluated 253 patients who received allo‐HSCT from 2007 to 2015 at our institute. HHV‐6 encephalitis/myelitis was defined as HHV‐6 DNA detection in the cerebrospinal fluid or peripheral blood by polymerase chain reaction in the presence of typical manifestations without other concurrent condition that led to the manifestations. Results: HHV‐6 encephalitis/myelitis occurred in 11 patients (4.5%) (9 encephalitis, 3.7%; 2 myelitis, 0.8%). Multivariate analysis showed that CBT, mycophenolate mofetil (MMF) for graft‐versus‐host disease prophylaxis, history of allogeneic hematopoietic stem cell transplantation (allo‐HSCT), and engraftment syndrome (ES) were significantly associated with incidence of HHV‐6 encephalitis/myelitis ( P =.025, P =.017, P =.017, and P =.014, respectively). Conclusion: Although it has been shown that CBT, ES, and history of allo‐HSCT are risk factors for HHV‐6 encephalitis/myelitis, our study demonstrated MMF is also a risk factor for the disease.