Mydriatics release from solid and semi-solid ophthalmic formulations using different in vitro methods. (2nd September 2017)

• Record Type: Journal Article
• Authors: Pescina, Silvia; Macaluso, Claudio; Gioia, Gloria Antonia; Padula, Cristina; Santi, Patrizia; Nicoli, Sara
• Is Part Of: Drug development and industrial pharmacy. Volume 43:Number 9(2017)
• Page Start: 1472
• Page End: 1479
• Publication Date: 2017-09-02
• Subjects: Mydriatic -- ocular drug delivery -- in vitro release -- film -- gel -- vial method -- inclined plane -- diffusion cell -- Mydriasert®; Pharmaceutical chemistry -- Periodicals; Pharmaceutical industry -- Periodicals; Drug Industry -- Periodicals; Technology, Pharmaceutical -- Periodicals; 615.05
• DOI: 10.1080/03639045.2017.1318910
• Languages: English
• ISSNs: 0363-9045

Abstract

Abstract: The aim of the present paper was the development of semi-solid (hydrogels) and solid (film) ophthalmic formulations for the controlled release of two mydriatics: phenylephrine and tropicamide. The formulations – based on polyvinylalcohol and hyaluronic acid – were characterized, and release studies were performed with three different in vitro set-ups, i.e. Franz-type diffusion cell, vial method and inclined plane; for comparison, a solution and a commercial insert, both clinically used to induce mydriasis, were evaluated. Both gels and film allowed for a controlled release of drugs, appearing a useful alternative for mydriatics administration. However, the release kinetic was significantly influenced by the method used, highlighting the need for optimization and standardization of in vitro models for the evaluation of drug release from ophthalmic dosage forms.