Solvent-free synthesis of polyhydroquinoline and 1, 8-dioxodecahydroacridine derivatives through the Hantzsch reaction catalyzed by a natural organic acid: A green method. Issue 12 (18th June 2017)

• Record Type: Journal Article
• Authors: Sehout, Imène; Boulcina, Raouf; Boumoud, Boudjemaa; Boumoud, Taous; Debache, Abdelmadjid
• Is Part Of: Synthetic communications. Volume 47:Issue 12(2017)
• Page Start: 1185
• Page End: 1191
• Publication Date: 2017-06-18
• Subjects: 1, 8-Dioxodecahydroacridine -- ascorbic acid -- Hantzsch reaction -- polyhydroquinoline -- solvent-free conditions; Organic compounds -- Synthesis -- Periodicals; Chemistry, Organic; Synthesis; 547.205
• DOI: 10.1080/00397911.2017.1316406
• Languages: English
• ISSNs: 0039-7911

Abstract

ABSTRACT: Solvent-free and high yielding one-pot synthesis of 1, 8-dioxodecahydroacridine and polyhydroquinoline derivatives have been described through Hantzsch condensation of various aldehydes, ammonium acetate with cyclic 1, 3-dicarbonyl compounds and ethyl acetoacetate in a very simple, efficient, and environmentally benign method using ascorbic acid as a nontoxic organocatalyst. GRAPHICAL ABSTRACT: