Synergistic Effect of Pd/C and Novozyme 435 on the Dynamic Kinetic Resolution of 1, 1, 1-trifluoroisopropylamine. Issue 9 (1st September 2016)

• Record Type: Journal Article
• Authors: Jiang, Chengjun; Cheng, Guilin
• Is Part Of: Chemical engineering communications. Volume 203:Issue 9(2016)
• Page Start: 1222
• Page End: 1226
• Publication Date: 2016-09-01
• Subjects: Catalytic synthesis -- Central composite design -- Dynamic kinetic resolution -- Enzymes -- Response surface methodology -- Trifluoroisopropylamine; Chemical engineering -- Periodicals; 660.205
• DOI: 10.1080/00986445.2016.1160229
• Languages: English
• ISSNs: 0098-6445

Abstract

Abstract : Response surface methodology (RSM) was successfully applied to study the synergistic effect of Pd/C and Novozyme 435 on the dynamic kinetic resolution of 1, 1, 1-trifluoroisopropylamine (TFPA). The variables taken into consideration were reaction temperature, substrate concentration, the Pd/C amount, and the Novozyme 435 amount. A statistical model was used to evaluate the influence of the variables on the conversion and enantiomeric excess (ee). It was found that the interaction between the Novozyme 435 and Pd/C was a significant parameter that affected TFPA conversion. The optimum conditions for RSM were: reaction temperature of 35°C, substrate (±) − 1 concentration of 0.4 mol/L, 60 g/L of Novozyme 435, and 42.4 g/L of Pd/C (3 wt% of Pd on active carbon). The actual experimental conversion was 95.6% under optimum conditions, which was comparable to the maximum predicted value of 95.7%.