Dynamic model of vascular-targeted photodynamic therapy. Issue 10 (27th July 2017)

• Record Type: Journal Article
• Authors: Hu, Xiao-ming; He, Linhuan; Zhao, Yi
• Is Part Of: Computer methods in biomechanics and biomedical engineering. Volume 20:Issue 10(2017)
• Page Start: 1056
• Page End: 1065
• Publication Date: 2017-07-27
• Subjects: Photodynamic therapy -- computer simulation -- singlet oxygen -- hypoxia -- photothermolysis; Biomechanics -- Data processing -- Periodicals; Biomedical engineering -- Periodicals; Biomechanics -- Periodicals; Biomedical Engineering -- methods -- Periodicals; Computing Methodologies -- Periodicals; 612.7
• DOI: 10.1080/10255842.2017.1331344
• Languages: English
• ISSNs: 1025-5842

Abstract

Abstract: Vascular-targeted photodynamic therapy has shown efficiency in treating port wine stains. A dynamic model that incorporates blood flow, kinetic diffusion, oxygen and photosensitizer consumption and reaction, and light modulation is proposed to reveal the interactions among light, photosensitizer, and oxygen. Simulation results show that pulse light modulation synchronized with heartbeats hold the advantage of increased singlet oxygen accumulation, higher oxygen concentration and lower temperature. Meanwhile, constant light treatment is advantageous in terms of higher temperature, lower total oxygen concentration and singlet oxygen accumulation. Therefore, the optimized treatment protocol may involve a balance among the phototoxicity, hypoxia, and photothermolysis.