MiR-126 affects the invasion and migration of glioma cells through GATA4. (18th August 2017)

• Record Type: Journal Article
• Authors: Xu, Yifan; Xu, Wu; Lu, Tianyu; Dai, Yuxiang; Liang, Weibang
• Is Part Of: Artificial cells, nanomedicine, and biotechnology. Volume 45:Number 6(2017)
• Page Start: 1247
• Page End: 1253
• Publication Date: 2017-08-18
• Subjects: miR-126 -- GATA4 -- glioma -- invasion; Artificial cells -- Periodicals; Nanotechnology -- Periodicals; Blood substitutes -- Periodicals; Tissue engineering -- Periodicals; Molecules -- Periodicals; Biotechnology -- Periodicals; 615.39
• DOI: 10.1080/21691401.2016.1226179
• Languages: English
• ISSNs: 2169-1401

Abstract

Abstract: We aimed to explore the relationship between miR-126 and glioma. miR-126 was highly expressed in low-grade clinical glioma tissue samples but lowly expressed in high-grade ones ( P < .01). A human endogenous miR-126 expression vector was constructed. The migration capacity of cells transfected with the vector significantly decreased ( P < .05). Up-regulation of miR-126 suppressed GATA4 protein expression. After transfection, they slightly contracted and became ovally or spherically shaped. F-actin significantly reduced, and microfilaments shortened or disappeared. The number of membrane-penetrating cells significantly decreased ( P < .01). miR-126 inhibits the migration and invasion of glioma cells, which may be linked to GATA4 as a target gene.