Early second-trimester plasma levels of NT-proBNP in women who subsequently develop early-onset preeclampsia. (17th September 2017)

• Record Type: Journal Article
• Authors: Junus, Katja; Wikström, Anna-Karin; Larsson, Anders; Olovsson, Matts
• Is Part Of: Journal of maternal-fetal & neonatal medicine. Volume 30:Number 18(2017)
• Page Start: 2163
• Page End: 2165
• Publication Date: 2017-09-17
• Subjects: B-type natriuretic peptide -- biomarker -- BNP -- hypertension -- pregnancy; Obstetrics -- Periodicals; Perinatology -- Periodicals; Infants (Newborn) -- Diseases -- Periodicals; Neonatology -- Periodicals; 618.2
• DOI: 10.1080/14767058.2016.1241992
• Languages: English
• ISSNs: 1476-7058

Abstract

Abstract: Plasma levels of NT-proBNP are elevated in women with preeclampsia at the time of diagnosis. The objective of this case-control study was to evaluate N-terminal proBNP (NT-proBNP) in maternal plasma as an early second-trimester biomarker for prediction of early-onset preeclampsia. In early second-trimester samples, women who later developed preeclampsia at gestational age 34 wk + 0 or earlier ( n = 16) had similar plasma levels of NT-proBNP (median 51.8, range 26.1–131.9 pg/ml) as women with uncomplicated pregnancy outcomes ( n = 43) (53.0, 14.9–184.2 pg/ml). The early second-trimester level of NT-proBNP cannot therefore be used as a predictive biomarker of early-onset preeclampsia.