Highly sensitive determination of non-steroidal anti-inflammatory drug nimesulide using electrochemically reduced graphene oxide nanoribbons. Issue 52 (29th June 2017)

• Record Type: Journal Article
• Authors: Govindasamy, Mani; Mani, Veerappan; Chen, Shen-Ming; Maiyalagan, Thandavarayan; Selvaraj, S.; Chen, Tse-Wei; Lee, Shih-Yi; Chang, Wen-Han
• Is Part Of: RSC advances. Volume 7:Issue 52(2017)
• Page Start: 33043
• Page End: 33051
• Publication Date: 2017-06-29
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/c7ra02844j
• Languages: English
• ISSNs: 2046-2069

Abstract

Abstract : Preparation of an electrochemically reduced graphene nanoribbon (ER-GONR) film modified screen-printed carbon electrode for the highly sensitive determination of nimesulide. Abstract : The excess use of nimesulide (NIM) causes acute side effects to gastrointestinal, central nervous and genitourinary systems and hence its rapid, sensitive determination is highly important. We describe a robust electrochemical sensor based on electrochemically reduced graphene oxide nanoribbons (ER-GONRs) modified on a screen-printed carbon electrode (SPCE) for detecting NIM in pharmaceutical formulations and biological medium. Compared with parental multiwalled carbon nanotubes (MWCNTs), ER-GONRs possess rich edge defects, abundant functional groups, high area-normalized edge-plane structures and chemically active sites and hence they can be a superior electrocatalyst and signal amplifier for electroanalytical applications. ER-GONRs/SPCE exhibited excellent sensing performance towards NIM. The linear range was 1.0 × 10 −8 to 1.50 × 10 −3 M and the detection limit was 3.50 (±1.57) nM. In addition, the ER-GONRs/SPCE showed excellent real-time sensing applications in NIM tablet and human urine samples, which could find potential applicability in drug and clinical analysis. The combined advantages of SPCE technology and ER-GONRs make this method a robust, low-cost, reproducible, sensitive and easy-to-use sensor.