Accelerating chemical reactions by molecular sledding. Issue 47 (26th May 2017)

• Record Type: Journal Article
• Authors: Zhang, Lei; Zheng, Lifei; Meng, Zhuojun; Balinin, Konstantin; Loznik, Mark; Herrmann, Andreas
• Is Part Of: Chemical communications. Volume 53:Issue 47(2017)
• Page Start: 6331
• Page End: 6334
• Publication Date: 2017-05-26
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c7cc02500a
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : The speed-up of covalent bond formation and cleavage were both achieved by utilizing sliding peptide-modified functionalities moving on DNA. Abstract : The speed-up of covalent bond formation was achieved between a sulfhydryl group and a 2-bromopropionic acid derivative by utilizing sliding peptide-modified substrates. Moreover, a new type of DNA cleaving reagent was developed, consisting of pVIc covalently coupled to verteporfin. This peptide–porphyrin conjugate allowed targeting of DNA and resulted in increased photodegradation of double-stranded nucleic acids.