Fabrication of a graphene/C60 nanohybrid via γ-cyclodextrin host–guest chemistry for photodynamic and photothermal therapy. Issue 25 (20th June 2017)

• Record Type: Journal Article
• Authors: Hu, Zhen; Wang, Cheng; Zhao, Feng; Xu, Xirong; Wang, Shuhong; Yu, Long; Zhang, Dayu; Huang, Yudong
• Is Part Of: Nanoscale. Volume 9:Issue 25(2017)
• Page Start: 8825
• Page End: 8833
• Publication Date: 2017-06-20
• Subjects: Nanoscience -- Periodicals; Nanotechnology -- Periodicals; 620.505
• DOI: 10.1039/c7nr02922e
• Languages: English
• ISSNs: 2040-3364

Abstract

Abstract : Herein, we report a novel strategy to combine C60 with graphene via host–guest chemistry for targeted phototherapy. Abstract : The wonderful chemical structures and characteristics of low-dimensional carbon materials have exciting applications in life sciences. In the present study, we developed a facile strategy to conjugate C60 with graphene via host–guest chemistry for targeted phototherapy. A versatile carrier based on folic acid-functionalized graphene (GO-FA) and comprising γ-cyclodextrin (γ-CD) at its surface was assembled via π–π interaction, creating hybrid structures with drug storage and tumor targeting properties. This γ-CD-modified graphene (GO-FA/Py-γ-CD) is capable of hosting pristine C60 molecules for the fabrication of a GO-FA/Py-γ-CD/C60 nanohybrid. The hybridization of GO-FA, γ-CD, and C60 hinders the aggregation of C60, promotes cellular uptake, enhances light absorption, and finally demonstrates enhanced phototherapy effects of GO-FA/Py-γ-CD/C60 . Under Xe lamp irradiation (2 W cm −2 ) for 4 min, GO-FA/Py-γ-CD/C60 simultaneously causes heating and intracellular ROS production, which further significantly reduces the cell viability to 16.2% at low content of loading (30 μg mL −1 ). Moreover, it represents an excellent tumor killing efficiency, better than that of the other reported graphene/C60 nanohybrids; thus, this material is suitable for applications in phototherapy of cancer.