Fabrication of core–shell Ag@pDA@HAp nanoparticles with the ability for controlled release of Ag+ and superior hemocompatibility. Issue 47 (6th June 2017)

• Record Type: Journal Article
• Authors: Chen, Keling; Xie, Kenan; Long, Qin; Deng, Lijun; Fu, Zhiqiang; Xiao, Huanhuan; Xie, Lu
• Is Part Of: RSC advances. Volume 7:Issue 47(2017)
• Page Start: 29368
• Page End: 29377
• Publication Date: 2017-06-06
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/c7ra03494f
• Languages: English
• ISSNs: 2046-2069

Abstract

Abstract : We report a convenient and effective method to prepare Ag-NPs and core–shell Ag@pDA@HAp-NPs. Abstract : Silver nanoparticles (Ag-NPs) are a type of crucial bactericide due to their excellent antibacterial properties. However, the application of Ag-NPs in clinics and in bone tissue engineering is hampered because of their unabiding antibacterial efficacy and undesirable biological properties such as cytotoxicity and inferior hemocompatibility. In this study, Ag-NPs were modified with polydopamine (pDA) and hydroxyapatite (HAp) to prepare novel and multifunctional core (Ag-NPs)–shell (pDA)–shell (HAp) nanoparticles (Ag@pDA@HAp-NPs). The Ag + release rate was reduced by about 80% on the first day, and then Ag + was slowly released, which implied that the core–shell Ag@pDA@HAp-NPs could effectively control the release of Ag + . The core–shell Ag@pDA@HAp-NPs could obviously inhibit the growth of E. coli and S. aureus, and the bactericide rate of the Ag@pDA@HAp-NPs was up to 99.99% after being cultured for 24 h. Furthermore, the synthesized Ag@pDA@HAp-NPs exhibited superior hemocompatibility due to the favorable blood compatibility of the pDA coating and HAp shell as well as the controlled release of Ag + . Thus, the core–shell Ag@pDA@HAp-NPs, with the ability for the controlled release of Ag + and superior hemocompatibility, are promising for reducing cytotoxicity and achieving long-term antibacterial properties, and could have potential applications in clinics and in bone tissue engineering.