Copper‐Catalyzed Domino Reaction Involving C–C Bond Cleavage To Construct 2‐Aryl Quinazolinones. Issue 13 (25th March 2014)

• Record Type: Journal Article
• Authors: Wang, Li‐Xia; Xiang, Jun‐Feng; Tang, Ya‐Lin
• Is Part Of: European journal of organic chemistry. Issue 13(2014)
• Page Start: 2682
• Page End: 2685
• Publication Date: 2014-03-25
• Subjects: Synthetic methods -- Domino reactions -- Cleavage reactions -- Nitrogen heterocycles -- Copper; Chemistry, Organic -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1002/ejoc.201400108
• Languages: English
• ISSNs: 1434-193X

Abstract

Abstract: A copper‐catalyzed approach for the synthesis of 2‐aryl‐quinazolinones through a domino reaction involving C–C bond cleavage is described. This protocol involves intramolecular C–C bond cleavage to construct 2‐aryl‐quinazolinones, which may offer an alternative method to prepare medically important quinazolinone derivatives and a new strategy for C–C bond cleavage. Besides C–C bond cleavage, this domino reaction includes N ‐arylation and benzylic C–H amidation. Abstract : A copper‐catalyzed approach for the synthesis of 2‐aryl‐quinazolinones through a domino reaction involving C–C bond cleavage is described. This transformation offers an alternative method to prepare medically important quinazolinone derivatives and a new strategy for C–C bond cleavage.