Single-crystal structure analysis of designer drugs circulating in the Japanese drug market by the synchrotron radiation X-ray diffraction. Issue 2 (20th June 2017)

• Record Type: Journal Article
• Authors: Hashimoto, Takashi; Hanajiri, Ruri; Yasuda, Nobuhiro; Nakamura, Yuki; Mizuno, Nobuhiro; Honda, Sadao; Hayakawa, Shinjiro; Nishiwaki, Yoshinori; Kimura, Shigeru
• Is Part Of: Powder diffraction. Volume 32:Issue 2(2017)
• Page Start: 112
• Page End: 117
• Publication Date: 2017-06-20
• Subjects: synchrotron XRD, -- designer drugs; Powder metallurgy -- Periodicals; Materials -- Analysis -- Periodicals; 620.1127
• DOI: 10.1017/S0885715617000379
• Languages: English
• ISSNs: 0885-7156

Abstract

Abstract : Over the past 20 years, many designer drugs derived from controlled substances have been widely distributed as easily available psychoactive substances and have become a serious problem in Japan. In order to determine the absolute structures of four new designer drugs derived from medicines (methylphenidate and phenmetrazine) X-ray single-crystal structure analyses were performed using the BL26B1 beamline of synchrotron radiation facility SPring-8. The results show that the molecular configuration of these designer drugs (having two asymmetric carbons), which were distributed in the illegal drug market had threo-forms as found for methylphenidate and phenmetrazine.