Ruthenium(ii)-catalyzed C–H alkenylation/annulation cascade for the rapid synthesis of benzoimidazoisoindoles. Issue 7 (20th April 2017)

• Record Type: Journal Article
• Authors: Selvaraju, Manikandan; Wang, Ying-Lien; Sun, Chung-Ming
• Is Part Of: Organic chemistry frontiers. Volume 4:Issue 7(2017)
• Page Start: 1358
• Page End: 1362
• Publication Date: 2017-04-20
• Subjects: Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1039/c7qo00136c
• Languages: English
• ISSNs: 2052-4110

Abstract

Abstract : A one pot synthesis of benzimidazole-fused isoindoles from 2-arylbenzimidazole and conjugated alkenes has been explored. The strategy involved the ruthenium-catalyzed formation of C–C and C–N bonds and a new five-membered ring. Abstract : An efficient one pot synthesis of benzimidazole-fused isoindoles from 2-arylbenzimidazole and readily available conjugated alkenes has been explored. The developed domino strategy involved the ruthenium-catalyzed formation of two distinct C–C and C–N bonds and one new five-membered ring to afford a polycyclic molecule. The rapid and base-free reaction conditions and the broader substrate scope are salient features of this novel protocol. The ruthenium-catalyzed tandem reaction provides a direct tool for the easy and rapid access to a new benzoimidazoisoindole scaffold.