Pathology and molecular updates in tumors of the prostate: towards a personalized approach. (3rd August 2017)

• Record Type: Journal Article
• Authors: Gasparrini, Silvia; Cimadamore, Alessia; Mazzucchelli, Roberta; Scarpelli, Marina; Massari, Francesco; Raspollini, Maria Rosaria; Galosi, Andrea B.; Lopez-Beltran, Antonio; Cheng, Liang; Montironi, Rodolfo
• Is Part Of: Expert review of molecular diagnostics. Volume 17:Number 8(2017)
• Page Start: 781
• Page End: 789
• Publication Date: 2017-08-03
• Subjects: Prostate cancer -- intraductal carcinoma of the prostate -- Gleason grading -- prognostic grade grouping -- liquid biopsies -- urinary biomarkers -- TMPRSS2-ERG -- AR-V7; Molecular diagnosis -- Periodicals; 616.0758205
• DOI: 10.1080/14737159.2017.1341314
• Languages: English
• ISSNs: 1473-7159

Abstract

ABSTRACT: Introduction : Treatment planning in patients with prostate neoplasms and prostate cancer (PCa) is generally based on the clinical and pathological molecular markers obtained from prostate needle biopsy and/or radical prostatectomy specimens. Area covered : Pathology of prostate neoplasms is evolving rapidly. Emerging trends include new additions to the 2016 World Health Organization (WHO) tumor classification as well as expanded diagnostic utility of biomarkers and molecular testing in tissue specimens, liquid biopsies and urinary samples, with the following purposes: diagnosis, prognosis and prediction. Expert commentary : The new additions to the 2016 WHO tumor classification, which include pathological definition of Intraductal carcinoma of the prostate (IDC-P) and of a new grading system for PCa, as well as identification of molecular markers, such as TMPRSS2-ERG and AR-V7, may pave the way to personalized therapy for patients with prostate tumors.