Chemical constituents and in vitro biological activities of Eremurus spectabilis leaves. Issue 15 (3rd August 2017)

• Record Type: Journal Article
• Authors: Karakaya, Leyla; Akgül, Yurdanur; Nalbantsoy, Ayşe
• Is Part Of: Natural product research. Volume 31:Issue 15(2017)
• Page Start: 1786
• Page End: 1791
• Publication Date: 2017-08-03
• Subjects: Eremurus spectabilis -- Isolated compounds -- Cytotoxicity and iNOS activities; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2017.1292268
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: In the present study, phytochemical investigation of the young leaves of Eremurus spectabilis let to the isolation six compounds (1–6 ). Their structure was determined by spectroscopic analysis and comparison with the literature data. All compounds were isolated for the first time from E. spectabilis . Isolated compounds and prepared extracts did not show cytotoxic activity against HeLa (Human cervix adenocarcinoma), A-549 (Human alveolar adenocarcinoma), MCF-7 (Human breast adenocarcinoma), mPANC96 (Human pancreas adenocarcinoma), U87MG (Glioblastoma), PC3 (Prostate), CaCo-2 (Colon), HEK293 (Human embryonic kidney cells) cell lines. RAW 264.7 (murine macrophage cell lines) was used to determine the inhibition levels of inducible nitric oxide synthase (iNOS).The hexane extract was found to be active in terms of inhibition of iNOS (IC50 : 25 μg/ml). Abstract :