Combining batch and continuous flow setups in the end-to-end synthesis of naturally occurring curcuminoids. Issue 3 (28th February 2017)

• Record Type: Journal Article
• Authors: Carmona-Vargas, Christian C.; de C. Alves, Leandro; Brocksom, Timothy J.; de Oliveira, Kleber T.
• Is Part Of: Reaction chemistry & engineering. Volume 2:Issue 3(2017)
• Page Start: 366
• Page End: 374
• Publication Date: 2017-02-28
• Subjects: Reaction mechanisms (Chemistry) -- Periodicals; Chemical engineering -- Periodicals; Chemical engineering; Reaction mechanisms (Chemistry); Periodicals; 547.705
• DOI: 10.1039/c6re00207b
• Languages: English
• ISSNs: 2058-9883

Abstract

Abstract : A successful end-to-end continuous flow synthesis of pure curcumin (1 ) and two other natural derivatives present in turmeric is described. Abstract : A successful end-to-end continuous flow synthesis of pure curcumin (1 ) and two other natural derivatives present in turmeric is described. Batch and continuous flow conditions were combined in order to develop the end-to-end process. Three operations were telescoped yielding the three different natural curcuminoids in a safe, gram-scale and reproducible manner.