Assessment of treatment response after lung stereotactic body radiotherapy using diffusion weighted magnetic resonance imaging and positron emission tomography: A pilot study. Issue 92 (July 2017)

• Record Type: Journal Article
• Authors: Shintani, Takashi; Matsuo, Yukinori; Iizuka, Yusuke; Mitsuyoshi, Takamasa; Umeoka, Shigeaki; Nakamoto, Yuji; Mizowaki, Takashi; Togashi, Kaori; Hiraoka, Masahiro
• Is Part Of: European journal of radiology. Issue 92(2017)
• Page Start: 58
• Page End: 63
• Publication Date: 2017-07
• Subjects: Stereotactic body radiotherapy -- Lung cancer -- Local recurrence -- Diffusion-weighted MRI -- PET; Medical radiology -- Periodicals; Radiology -- Periodicals; Radiologie médicale -- Périodiques; Medical radiology; Periodicals; 616.075705
• DOI: 10.1016/j.ejrad.2017.04.022
• Languages: English
• ISSNs: 0720-048X

Abstract

Abstract: Background and purpose: There is no early predictor of treatment response after lung stereotactic body radiotherapy (SBRT). We conducted this pilot study to evaluate whether serial diffusion weighted magnetic resonance imaging (DW-MRI) or positron emission tomography (PET) could predict response after SBRT. Material and methods: Early stage non-small cell lung cancer patients who received SBRT were eligible. DW-MRI and PET were undertaken pretreatment and every 3 months after SBRT in the first year. Patients with <1 year of follow-up were excluded from the analysis. The apparent diffusion coefficient (ADC) value and maximum standardized uptake value (SUVmax ) of tumors were measured and compared between groups with or without local recurrence (LR). Results: Fifteen patients were enrolled and the data of 14 patients were analyzed. The median ADC value was significantly lower in patients with LR (n = 3) than in those without LR (n = 11) at 3 and 6 months (1.11 vs. 1.54 and 0.98 vs. 1.69 [×10 −3 mm 2 /s]; p = 0.039 and 0.012, respectively) while there was no significant difference pretreatment and at 9 and 12 months after treatment. No significant difference was observed in the SUVmax at any time point. Conclusions: DW-MRI could be an early predictor of treatment response after lung SBRT.