11C Click Chemistry Using [11C]Methyl Azide: Simplified, Versatile, and Practical Alternative Access to [11C]Nucleosides and [11C]Oligonucleotides for PET Imaging. Issue 7 (24th January 2013)

• Record Type: Journal Article
• Authors: Bordenave, Thomas; Hazari, Puja Panwar; James, Damien; Mishra, Anil K.; Szlosek‐Pinaud, Magali; Fouquet, Eric
• Is Part Of: European journal of organic chemistry. Issue 7(2013)
• Page Start: 1214
• Page End: 1217
• Publication Date: 2013-01-24
• Subjects: Isotopic labeling -- Positron emission tomography -- Radiochemistry -- Click chemistry -- Nucleosides; Chemistry, Organic -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1002/ejoc.201201379
• Languages: English
• ISSNs: 1434-193X

Abstract

Abstract: This communication reports the simplified formation of methyl azide and its use in the Huisgen cycloaddition for the rapid, efficient, and selective labeling of modified nucleosides and oligonucleotides. The transposition to radioactive chemistry is presented, and this furnishes practical access to [ 11 C]methylated tracers for positron emission tomography imaging. Abstract : Click chemistry in its "hot" version: A one‐step approach to nucleosides opens the way to the development of a new class of positron emission tomography (PET) tracers.