Copper‐Catalyzed Oxidative Coupling of Carboxylic Acids with N, N‐Dialkylformamides: An Approach to the Synthesis of Amides1. Issue 7 (24th January 2013)

• Record Type: Journal Article
• Authors: Kumar, P. Santhosh; Kumar, G. Sathish; Kumar, R. Arun; Reddy, N. Veera; Rajender Reddy, K.
• Is Part Of: European journal of organic chemistry. Issue 7(2013)
• Page Start: 1218
• Page End: 1222
• Publication Date: 2013-01-24
• Subjects: Synthetic methods -- Cross‐cou­pling -- Amides -- Carboxylic acids -- Copper; Chemistry, Organic -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1002/ejoc.201201544
• Languages: English
• ISSNs: 1434-193X

Abstract

Abstract: A new synthetic approach for amide bond formation through the oxidative coupling of N, N ‐dialkylformamides with carboxylic acids was achieved by using a copper catalyst. Furthermore, this method was applied in the coupling of chiral amino acids in which the stereochemistry was retained in the resulting amide products. Abstract : A new synthetic approach to amide bond formation through the oxidative coupling of N, N ‐dialkylformamides with carboxylic acids was achieved by using a copper catalyst and aqueous tert ‐butyl hydroperoxide (TBHP) as a sacrificial oxidant. Furthermore, this method was applied in the coupling of chiral amino acids in which the stereochemistry was retained in the resulting amide products.