Nanoscale hydrophilic colloids with high relaxivity and low cytotoxicity based on Gd(iii) complexes with Keplerate polyanions. (13th June 2017)

• Record Type: Journal Article
• Authors: Elistratova, Julia; Akhmadeev, Bulat; Gubaidullin, Aidar; Korenev, Vladimir; Sokolov, Maxim; Nizameev, Irek; Stepanov, Alexey; Ismaev, Ildus; Kadirov, Marsil; Voloshina, Alexandra; Mustafina, Asiya
• Is Part Of: New journal of chemistry. Volume 41:Number 13(2017)
• Page Start: 5271
• Page End: 5275
• Publication Date: 2017-06-13
• Subjects: Chemistry -- Periodicals; Chimie -- Périodiques; 540
• DOI: 10.1039/c7nj01237c
• Languages: English
• ISSNs: 1144-0546

Abstract

Abstract : Efficient hydrophilic stabilization of Gd(iii ) complexes with Keplerate polyanions for high relaxivity, colloid stability and low cytotoxicity. Abstract : The work introduces for the first time Mo-132-type Keplerates (Kp) and Gd 3+ ions as a basis for the one-pot synthesis of aqueous colloids with high longitudinal relaxivity ( r 1 = 96.4 mM −1 s −1 at 20 MHz). The hydrophilic coating of small (3–5 nm) Gd x (Kp) y -based cores provides their colloid stabilization, protection from degradation and low cytotoxicity.