Cascade Palladium‐ and Copper‐Catalysed Aromatic Heterocycle Synthesis: The Emergence of General Precursors. Issue 3 (11th December 2012) - Ball, Catherine J.
Abstract: Several privileged starting materials that allow access to a variety of different heterocyclic scaffolds through judicious choice of reaction conditions (and coupling partner) have emerged. This microreview focuses on the development and use of four of these starting material types in cascade reactions involving the palladium‐ or copper‐catalysed formation of aromatic carbon–nitrogen, carbon–oxygen or carbon–sulfur bonds. Abstract : Over the last decade, four precursor types have been established as broadly general substrates in heterocycle synthesis. By appropriate choice of catalyst and coupling partner, these four precursor types can be converted into a wide range of aromatic products.