Convergent evolution of the adaptive immune response in jawed vertebrates and cyclostomes: An evolutionary biology approach based study. (October 2017)

• Record Type: Journal Article
• Authors: Morales Poole, Jose Ricardo; Paganini, Julien; Pontarotti, Pierre
• Is Part Of: Developmental and comparative immunology. Volume 75(2017)
• Page Start: 120
• Page End: 126
• Publication Date: 2017-10
• Subjects: Immunology -- Periodicals; Developmental immunology -- Periodicals; 616.079
• DOI: 10.1016/j.dci.2017.02.011
• Languages: English
• ISSNs: 0145-305X

Abstract

Abstract: Two different adaptive immune systems (AIS) are present in the two phyla of vertebrates (jawed vertebrates and cyclostomes). The jawed vertebrate system is based on IG/TCR/RAG/MHC while the cyclostome system is based on VLRCs and AID-like enzymes both systems using homologous Cell types (B-cell and B-cell Like, T-cell and T-cell like). We will present our current view of the evolution of these two AISs and present alternative hypotheses that could explain the apparent convergent evolution of the two systems. We will also discuss why comparative immunology analyses should be based on evolutionary biology approaches and not on the scale of progress one.