Highly Regioselective Addition of Organozinc Reagents to 2‐Oxo‐1, 2‐dihydropyrimidine‐5‐carboxylates Activated by BF3·OEt2: Synthesis of 2‐Oxo‐1, 2, 3, 4‐tetrahydropyrimidine‐5‐carboxylates. Issue 27 (2nd August 2013) - Singh, Kamaljit
Abstract: The incorporation of alkyl as well as phenyl groups at C‐4, a key position of 2‐oxo‐1, 2, 3, 4‐tetrahydropyrimidine‐5‐carboxylates, responsible for antagonist/agonist switching of the calcium channel blocking activity of these compounds, has been achieved by the addition of organozinc reagents to the corresponding 2‐oxo‐1, 2‐dihydropyrimidine‐5‐carboxylate derivatives catalysed by BF3 OEt2 . Abstract : An efficacious diversification of the key C‐4 position of 2‐oxo‐1, 2‐dihydropyrimidine‐5‐carboxylates has been achieved through the addition of organozinc reagents.