Pathophysiology, screening and diagnosis of pulmonary hypertension in infants with bronchopulmonary dysplasia - A review of the literature. (June 2017)

• Record Type: Journal Article
• Authors: Altit, Gabriel; Dancea, Adrian; Renaud, Claudia; Perreault, Thérèse; Lands, Larry C.; Sant'Anna, Guilherme
• Is Part Of: Paediatric respiratory reviews. Volume 23(2017)
• Page Start: 16
• Page End: 26
• Publication Date: 2017-06
• Subjects: Prematurity -- Bronchopulmonary dysplasia -- Chronic neonatal lung disease -- Pulmonary vascular disease -- Echocardiography -- Screening -- Pulmonary hypertension; Pediatric respiratory diseases -- Periodicals; Respiratory organs -- Diseases -- Periodicals; Respiratory Tract Diseases -- Periodicals; Respiratory Therapy -- Periodicals; Child -- Periodicals; Appareil respiratoire -- Infections, chez l'enfant -- Périodiques; Appareil respiratoire -- Maladies, chez l'enfant -- Périodiques; 618.922
• DOI: 10.1016/j.prrv.2016.11.002
• Languages: English
• ISSNs: 1526-0542

Abstract

Summary: Bronchopulmonary dysplasia (BPD) is a common complication of extreme prematurity, which has increased over the last 20 years. BPD is associated with increased morbidities and mortality. It has been increasingly recognized that BPD affects overall lung development including the pulmonary vasculature. More recent studies have demonstrated an increased awareness of pulmonary arterial hypertension (PH) in BPD patients and recent international guidelines have advocated for better screening. This review will describe the current understanding of the pathophysiology of PH in infants with BPD, the in-depth assessment of the available literature linking PH and BPD, and propose an approach of screening and diagnosis of PH in infants with BPD.