Three‐Component Synthesis of Indanone‐Fused Spirooxindole Derivatives. Issue 21 (10th June 2013)

• Record Type: Journal Article
• Authors: Chen, Xue‐Bing; Liu, Xi‐Ming; Huang, Rong; Yan, Sheng‐Jiao; Lin, Jun
• Is Part Of: European journal of organic chemistry. Issue 21(2013)
• Page Start: 4607
• Page End: 4613
• Publication Date: 2013-06-10
• Subjects: Multicomponent reactions -- Fused‐ring systems -- Spiro compounds -- Heterocycles; Chemistry, Organic -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1002/ejoc.201300376
• Languages: English
• ISSNs: 1434-193X

Abstract

Abstract: A simple, straightforward and versatile multicomponent protocol for the synthesis of indanone‐fused spirooxindole derivatives has been developed. The strategy involves the one‐pot three‐component reaction of heterocyclic ketene aminals, 1 H ‐indene‐1, 3(2 H )‐dione and the dicarbonyl compounds isatins or acenaphthenequinone in an ethanol/water medium catalysed by p ‐TSA at reflux. Mild reaction conditions, operational simplicity, wide substrate scope and overall excellent yields make this method highly efficient for the library synthesis of indanone‐fused spirooxindole. Abstract : A simple, straightforward and versatile multicomponent protocol for the synthesis of indanone‐fused spirooxindole derivatives has been developed. The strategy involves the one‐pot three‐component reaction of heterocyclic ketene aminals, 1 H ‐indene‐1, 3(2 H )‐dione and the dicarbonyl compounds isatins or acenaphthenequinone in an ethanol/water medium catalysed by p ‐TSA at reflux.