One‐Step Stereoselective Synthesis of Trisubstituted Monofluoroalkenes from 3, 3, 3‐Trifluoropropionates. Issue 21 (13th June 2013)

• Record Type: Journal Article
• Authors: Lecea, Mercedes; Grassin, Adrien; Ferreiro‐Mederos, Leticia; Choppin, Sabine; Urbano, Antonio; Carreňo, M. Carmen; Colobert, Françoise
• Is Part Of: European journal of organic chemistry. Issue 21(2013)
• Page Start: 4486
• Page End: 4489
• Publication Date: 2013-06-13
• Subjects: Fluorine -- Alkenes -- Lithium -- Magnesium -- Stereoselectivity; Chemistry, Organic -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1002/ejoc.201300551
• Languages: English
• ISSNs: 1434-193X

Abstract

Abstract: Stereoselective synthesis of ( E )‐monofluoroalkenes was achieved in one step by condensation of organolithium or Grignard reagents with 3, 3, 3‐trifluoropropionates. Highly functionalized monofluoroalkenes were obtained in good to excellent yields and stereoselectivities. Abstract : ( E )‐Monofluoroalkenes were obtained in good yields and stereoelectivities by condensation of organolithium or Grignard reagents to methyl or benzyl 3, 3, 3‐trifluoropropionate.