Tandem Transformation of Nitro Compounds into N‐Methylated Amines: Greener Strategy for the Utilization of Methanol as a Methylating Agent. Issue 11 (18th May 2017)

• Record Type: Journal Article
• Authors: Paul, Bhaskar; Shee, Sujan; Chakrabarti, Kaushik; Kundu, Sabuj
• Is Part Of: Chemphyschem. Volume 18:Issue 11(2017)
• Page Start: 2370
• Page End: 2374
• Publication Date: 2017-05-18
• Subjects: methylation -- nitro compounds -- N-methylated amines -- ruthenium -- tandem reactions; Chemistry, Physical and theoretical -- Periodicals; 541.05
• DOI: 10.1002/cssc.201700503
• Languages: English
• ISSNs: 1439-4235

Abstract

Abstract: A simple air‐ and moisture‐stable, highly efficient ruthenium NNN pincer complex is reported for the first time to catalyze the tandem transformation of various aromatic and aliphatic nitro compounds into the corresponding N ‐methylated amines in up to 98 % yield by using methanol as a green methylating agent. Gram‐scale reactions of challenging nitro substrates demonstrated the practical application aspects of this catalytic system. Importantly, the N ‐methylamine moiety could be smoothly introduced to various complex molecular structures without using any expensive palladium/phosphine/amine‐based cross‐coupling reactions. Abstract : Know your N ‐Me : For the first time, the tandem transformation of various aromatic and aliphatic nitro compounds into the corresponding N ‐methylated amines by using methanol as a green methylating agent is reported. With a simple air‐ and moisture‐stable ruthenium NNN pincer complex as catalyst yields up to 98 % are obtained.