Catalytic Enantioconvergent Decarb­oxylative Allylic Alkylation of Allyl Indol­enin‐3‐carboxylates. Issue 19 (16th May 2013)

• Record Type: Journal Article
• Authors: Kaiser, Thomas M.; Yang, Jiong
• Is Part Of: European journal of organic chemistry. Issue 19(2013)
• Page Start: 3983
• Page End: 3987
• Publication Date: 2013-05-16
• Subjects: Enantioconvergent reactions -- Palladium -- Chirality -- Allylic compounds -- Boranes; Chemistry, Organic -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1002/ejoc.201300515
• Languages: English
• ISSNs: 1434-193X

Abstract

Abstract: A catalytic enantioconvergent process has been developed for the conversion of racemic allyl indolenin‐3‐carboxylates into enantiomerically enriched C3‐quaternary indolenines. A Pd‐catalyzed decarboxylative allylic alkylation reaction was employed for both stereoablation of the racemic allyl indolenin‐3‐carboxylates and enantioselective formation of the quaternary carbon center. Abstract : The enantioconvergent conversion of racemic allyl indolenin‐3‐carboxylates into enantiomerically enriched C3‐quaternary indolenines is reported. A Pd‐catalyzed decarboxylative allylic alkylation reaction is employed for both stereoablation and enantioselective formation of the quaternary carbon center.