(β‐D‐Ribofuranosyl)formamidine in the Design and Synthesis of 2‐(β‐D‐Ribofuranosyl)pyrimidines, Including RF‐Containing Derivatives. Issue 15 (4th April 2013)

• Record Type: Journal Article
• Authors: Iaroshenko, Viktor O.; Dudkin, Sergii; Sosnovskikh, Vyacheslav Ya.; Villinger, Alexander; Langer, Peter
• Is Part Of: European journal of organic chemistry. Issue 15(2013)
• Page Start: 3166
• Page End: 3173
• Publication Date: 2013-04-04
• Subjects: Nucleosides -- Drug design -- Drug discovery -- Fluorine -- Ribonucleosides -- Alkynes; Chemistry, Organic -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1002/ejoc.201300107
• Languages: English
• ISSNs: 1434-193X

Abstract

Abstract: A wide range of novel 2‐(β‐D ‐ribofuranosyl)pyrimidines, including R F ‐containing derivatives, have been synthesized by the reaction of (β‐D ‐ribofuranosyl)formamidine with various dielectrophilic substrates such as 3‐alkoxy‐ and 3‐chloro‐1‐(polyfluoroalkyl)propen‐1‐ones, 3‐nitro‐ and 3‐(phenylethynyl)chromones and heteroaryl acetylenic ketones. Abstract : Polyfluoroalkyl‐containing 2‐(β‐D ‐ribofuranosyl)pyrimidine derivatives have been synthesized by the reaction of (β‐D ‐ribofuranosyl)formamidine with dielectrophilic substrates such as 3‐alkoxy‐ and 3‐chloro‐1‐(polyfluoroalkyl)propen‐1‐ones, 3‐nitro‐ and 3‐(phenylethynyl)chromones and heteroaryl acetylenic ketones.