Palladium and visible-light mediated carbonylative Suzuki–Miyaura coupling of unactivated alkyl halides and aryl boronic acids. Issue 51 (13th June 2017)

• Record Type: Journal Article
• Authors: Roslin, Sara; Odell, Luke R.
• Is Part Of: Chemical communications. Volume 53:Issue 51(2017)
• Page Start: 6895
• Page End: 6898
• Publication Date: 2017-06-13
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c7cc02763j
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : An efficient carbonylative coupling of aryl boronic acids and unactivated alkyl halides under visible-light irradiation and low CO-pressure is presented. Abstract : Herein, a simple and efficient method for the palladium-catalyzed carbonylation of aryl boronic acids with unactivated alkyl iodides and bromides under visible-light irradiation, ambient temperature and low CO-pressure is presented. Notably, the procedure uses readily available equipment and an inexpensive palladium catalyst to generate the key alkyl radical intermediate. These mild conditions enabled the synthesis of a range of functionalized aryl alkyl ketones including the antipsychotic drug, melperone.