A novel indeno[1, 2-b]pyridinone derivative, a DNA intercalative human topoisomerase IIα catalytic inhibitor, for caspase 3-independent anticancer activity. Issue 51 (12th June 2017)

• Record Type: Journal Article
• Authors: Jeon, K. H.; Park, C.; Kadayat, T. M.; Shrestha, A.; Lee, E. S.; Kwon, Y.
• Is Part Of: Chemical communications. Volume 53:Issue 51(2017)
• Page Start: 6864
• Page End: 6867
• Publication Date: 2017-06-12
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c7cc02372c
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : A novel 2-(furan-2-yl)-4-(pyridin-2-yl)-5 H -indeno[1, 2- b ]pyridin-5-one (TI-1-190) was synthesized using a simple microwave-assisted method and its mode of action was systematically characterized. Abstract : A novel 2-(furan-2-yl)-4-(pyridin-2-yl)-5 H -indeno[1, 2- b ]pyridin-5-one (TI-1-190) was synthesized using a simple microwave-assisted method and its mode of action was systematically characterized. It is a DNA intercalative human topoisomerase IIα catalytic inhibitor with much stronger activity and less DNA toxicity than etoposide, a topoisomerase II poison. TI-1-190 displays caspase 3-independent anticancer activity, unlike etoposide.