Two-photon imaging of formaldehyde in live cells and animals utilizing a lysosome-targetable and acidic pH-activatable fluorescent probe. Issue 48 (2nd June 2017)

• Record Type: Journal Article
• Authors: Xie, Xilei; Tang, Fuyan; Shangguan, Xiaoyan; Che, Shiyi; Niu, Jinye; Xiao, Yongsheng; Wang, Xu; Tang, Bo
• Is Part Of: Chemical communications. Volume 53:Issue 48(2017)
• Page Start: 6520
• Page End: 6523
• Publication Date: 2017-06-02
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c7cc03050a
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : A two-photon fluorescent probe presented lysosomal targetability and an acidic pH-activatable response toward formaldehyde, and was applied to visualize formaldehyde in living systems. Abstract : Lyso-TPFP presents lysosomal targetability and an acidic pH-activatable response toward formaldehyde. Thus, it exclusively visualizes lysosomal formaldehyde and is immune against it in neutral cytosol and other organelles. In addition, two-photon fluorescence imaging endows Lyso-TPFP with the capability of in situ tracking formaldehyde in live cells and animals.