An injectable ionic hydrogel inducing high temperature hyperthermia for microwave tumor ablation. Issue 22 (16th May 2017)

• Record Type: Journal Article
• Authors: Wang, Jingyun; Wang, Dan; Yan, Hao; Tao, Lei; Wei, Yen; Li, Yongsan; Wang, Xing; Zhao, Wei; Zhang, Yu; Zhao, Lingyun; Sun, Xiaodan
• Is Part Of: Journal of materials chemistry. Volume 5:Issue 22(2017)
• Page Start: 4110
• Page End: 4120
• Publication Date: 2017-05-16
• Subjects: Materials -- Periodicals; Chemistry, Analytic -- Periodicals; Biomedical materials -- Research -- Periodicals; 543.0284
• DOI: 10.1039/c7tb00556c
• Languages: English
• ISSNs: 2050-750X

Abstract

Abstract : Microwave tumor ablation is of clinical significance and has been considered as a promising cancer minimally invasive therapy. Abstract : Microwave tumor ablation is of clinical significance and has been considered as a promising cancer minimally invasive therapy. One of the challenges in this field is the optimization of the susceptible agent. Herein, a novel chitosan-based ionic hydrogel which can induce rather high temperature hyperthermia as a susceptible agent for microwave ablation is reported. Owning to the high porosity of the hydrogel, a strong ion confinement effect can be realized, therefore, strong polarization under microwave exposure is ensured for rapid heat generation. In addition, the as-synthesized hydrogel has negligible bio-toxicity and excellent spatial stability in vivo which can guarantee a reproducible therapeutic effect for repeated treatment. In vivo anti-tumor investigation has demonstrated that excellent therapeutic efficiency can be achieved after repeated microwave thermal therapy with a rather low power density (2.0 W, 2.45 GHz). Further, computer simulation was conducted to elucidate the microwave heating mechanism. Our investigation provides a biocompatible and stable agent for microwave tumor ablation and demonstrates its great significance for potential clinical application.