Active MR‐temperature feedback control of dynamic interstitial ultrasound therapy in brain: In vivo experiments and modeling in native and coagulated tissues. Issue 9 (21st August 2014)

• Record Type: Journal Article
• Authors: NˈDjin, W. A.; Burtnyk, M.; Lipsman, N.; Bronskill, M.; Kucharczyk, W.; Schwartz, M. L.; Chopra, R.
• Is Part Of: Medical physics. Volume 41:Issue 9(2014)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2014-08-21
• Subjects: MRI: anatomic, functional, spectral, diffusion -- Clinical applications -- Biomedical instrumentation and transducers, including micro‐electro‐mechanical systems (MEMS) -- Biothermics and thermal processes in biology -- Ultrasonography; biological tissues -- biomedical MRI -- biomedical transducers -- biothermics -- brain -- numerical analysis -- temperature measurement -- ultrasonic therapy -- ultrasonic transducers; brain -- thermal therapy -- metastasis -- interstitial ultrasound -- MRT feedback; Involving electronic [emr] or nuclear [nmr] magnetic resonance, e.g. magnetic resonance imaging -- Ultrasound therapy -- Processes or apparatus for generating mechanical vibrations of infrasonic, sonic or ultrasonic frequency -- Measuring temperature; Measuring quantity of heat; Thermally‐sensitive elements not otherwise provided for -- Biological material, e.g. blood, urine; Haemocytometers; Brain -- Ultrasonography -- Tissues -- Tissue engineering -- Ultrasound therapy -- Tissue ablation -- Cancer -- Magnetic resonance imaging -- Ultrasonic attenuation; Medical physics -- Periodicals; Medical physics; Geneeskunde; Natuurkunde; Toepassingen; Biophysics; Periodicals; Periodicals; Electronic journals; 610.153
• DOI: 10.1118/1.4892923
• Languages: English
• ISSNs: 0094-2405

Abstract

Abstract : Purpose: : The recent clinical emergence of minimally invasive image‐guided therapy has demonstrated promise in the management of brain metastasis, although control over the spatial pattern of heating currently remains limited. Based on experience in other organs, the delivery of high‐intensity contact ultrasound energy from minimally invasive applicators can enable accurate spatial control of energy deposition, large treatment volumes, and high treatment rate. In this acute study, the feasibility of active MR‐Temperature feedback control of dynamic ultrasound heat deposition for interstitial thermal ablation in brain was evaluated in vivo . Methods: : A four‐element linear ultrasound transducer (f = 8.2 MHz) originally developed for transurethral ultrasound therapy was used in a porcine model for generating thermal ablations in brain interstitially. First, the feasibility of treating and retreating precisely in vivo brain tissues using stationary (non‐rotating device) ultrasound exposures was studied in two pigs. Experimental results were compared to numerical simulations for maximum surface acoustic intensities ranging from 5 to 20 W cm −2 . Second, active MRT feedback‐controlled ultrasound treatments were performed in three pigs with a rotating device to coagulate target volumes of various shapes. The acoustic power and rotation rate of the device were adjusted in real‐time based on MR‐thermometry feedback control to optimize heat deposition at the target boundary. Modeling of in vivo treatments were performed and compared to observed experimental results. Results: : Overall, the time‐space evolution of the temperature profiles observed in vivo could be well estimated from numerical simulations for both stationary and dynamic interstitial ultrasound exposures. Dynamic exposures performed under closed‐loop temperature control enabled accurate elevation of the brain tissues within the targeted region above the 55 °C threshold necessary for the creation of irreversible thermal damage. Treatment volumes ranging from 1 to 9 cm 3 were completed within 8 ± 3 min with a radial targeting error <2 mm on average (treatment rate: 0.7 ± 0.5 cm 3 /min). Tissue changes were visible on T1‐weighted contrast‐enhanced (T1w‐CE) images immediately after treatment. These changes were also evident on T2‐weighted (T2w) images acquired 2 h after the 1st treatment and correlated well with the MR‐thermometry measurements. Conclusions: : These results support the feasibility of active MRT feedback control of dynamic interstitial ultrasound therapy of in vivo brain tissues and confirm the feasibility of using simulations to predict spatial heating patterns in the brain.