Producing xylan/Eudragit® S100-based microparticles by chemical and physico-mechanical approaches as carriers for 5-aminosalicylic acid. (29th April 2013)

• Record Type: Journal Article
• Authors: Silva, Acarilia Eduardo; Oliveira, Elquio Eleamen; Gomes, Monique C. Salgado; Marcelino, Henrique Rodrigues; Silva, Karen C. Holanda; Souza, Bartolomeu Santos; Nagashima, Toshiyuki; Ayala, Alejandro Pedro; Oliveira, Anselmo Gomes; Egito, Eryvaldo Sócrates Tabosa do
• Is Part Of: Journal of microencapsulation. Volume 30:Number 8(2013:Dec.)
• Page Start: 787
• Page End: 795
• Publication Date: 2013-04-29
• Subjects: Cross-linking -- infrared spectroscopy -- polymer--biopolymer interaction -- spray-drying -- thermal analysis; Microencapsulation -- Periodicals; Controlled release technology -- Periodicals; 615.19
• DOI: 10.3109/02652048.2013.788087
• Languages: English
• ISSNs: 0265-2048

Abstract

Abstract: Xylan is a biopolymer found in a variety of cell wall plants. Eudragit® S-100 (ES100), a pH-dependent polymer, is used as a coating material in gastroresistant delivery systems. In this study, microparticles based on both polymers were produced by interfacial cross-linking polymerisation and/or spray-drying technique in order to investigate feasibility and stability of the systems. Size and morphology of the microparticles were characterised by optical and SEM while FT-IR, thermal analysis (TG/DTA), and X-ray diffraction (XRD) evaluated the drug–polymer interactions and the thermal behaviour of the systems. FT-IR confirmed the absence of chemical interaction between the polymers. TG/DTA analysis showed a higher stability for spray-dried microparticles and XRD data proved the amorphous feature of both carriers. The results reveal that xylan/ES100 microparticles can be produced by chemical or physico-mechanical ways, the latter being the best option due to the lack of toxic cross-linking agents and easy scale-up.