A glutathione-activatable photodynamic and fluorescent imaging monochromatic photosensitizer. Issue 22 (22nd May 2017)

• Record Type: Journal Article
• Authors: Li, Zhensheng; Liu, Yang; Chen, Li; Hu, Xiuli; Xie, Zhigang
• Is Part Of: Journal of materials chemistry. Volume 5:Issue 22(2017)
• Page Start: 4239
• Page End: 4245
• Publication Date: 2017-05-22
• Subjects: Materials -- Periodicals; Chemistry, Analytic -- Periodicals; Biomedical materials -- Research -- Periodicals; 543.0284
• DOI: 10.1039/c7tb00724h
• Languages: English
• ISSNs: 2050-750X

Abstract

Abstract : A GSH-activated fluorescent and ROS photosensitizer was synthesized from monochromatic BODIPY for selective bioimaging and photodynamic therapy. Abstract : The currently available photodynamic sensitizers usually lead to undesirable side effects, including dark toxicity from heavy-atom effect and nonspecific phototoxicity. To address these issues, we designed and prepared a smart photosensitizer from boron dipyrromethene (BODIPY), and the dark toxicity and phototoxicity were reduced via heavy-atom-free substitution and controllable photosensitization, respectively. Importantly, the photodynamic effect together with fluorescence imaging can be simultaneously switched on through the suppression of intramolecular charge transfer (ICT) and photoinduced electron-transfer (PeT) induced by cancer-related biothiol glutathione (GSH) in a buffer solution. Moreover, the sensitizer exhibits obvious fluorescence enhancement and selective phototoxicity towards cancer cells in a biological system upon irradiation. The present monochromatic photosensitizer, which combines fluorescence imaging and targeted PDT treatment within a single chromophore, possesses great potentials as a new activatable theranostic reagent in cancer therapy.