Water-mediated and promoted eco-friendly one-pot synthesis of azaarene substituted isoxazoles. (30th May 2017)

• Record Type: Journal Article
• Authors: Nagaraju, Dharavath; Rajanarendar, Eligeti; Praveen Kumar, Pittala; Nagi Reddy, Modugu
• Is Part Of: New journal of chemistry. Volume 41:Number 12(2017)
• Page Start: 4783
• Page End: 4787
• Publication Date: 2017-05-30
• Subjects: Chemistry -- Periodicals; Chimie -- Périodiques; 540
• DOI: 10.1039/c7nj01165b
• Languages: English
• ISSNs: 1144-0546

Abstract

Abstract : An efficient and green approach for the sp 3 C–H bond functionalization of 2-methyl azaarenes to 3-methyl-4-nitro-5-styrylisoxazoles in water has been described. Abstract : An efficient and green approach for the sp 3 C–H bond functionalization of 2-methyl azaarenes to 3-methyl-4-nitro-5-styrylisoxazoles in water has been described. Nitrostyrylisoxazoles were proven to be good CC electrophilic acceptors for the construction of various azaarene-containing Michael addition products. This method provides an efficient and environmentally benign method for the one-pot synthesis of biologically important azaarene-substituted isoxazole derivatives in good yields. The important aspects of the present methodology are the use of non-toxic solvent, that it is catalyst free, the ease of purification and the large substrate scope.